Opioids are commonly prescribed for chronic pain. In the United States, opioid prescribing increased 4-fold in the early 2000s, accompanied by increases in opioid-related overdose and addiction. Therefore, policy efforts have focused on reducing inappropriate or unnecessary opioid prescribing. Nonetheless, opioids remain a management option for chronic pain in selected patients. Because the prevalence of psychiatric conditions is high in those with chronic pain, psychiatrists often encounter patients prescribed opioids and can play an essential role in management. This article summarizes 5 key things for psychiatrists to know in this situation.