Bipolar disorder (BD) is a severe psychiatric disorder characterized by recurrent episodes of (hypo)mania and depression. With onset typically in early adulthood, an often chronic course, and increased risk of suicide, BD is a major source of disability and early mortality.1 Genetic epidemiology studies have estimated the heritability of BD to be approximately 60% to 85%, and genome-wide association studies (GWASs) have provided invaluable insights into disease biology. The largest published study to date, conducted by the Psychiatric Genomics Consortium (PGC), identified 30 BD-associated genomic loci in a sample of approximately 30 000 cases.2 However, most BD GWASs have been conducted in individuals of European ancestry.3
Mullins N, Huang H. Genetic Architecture of Bipolar Disorder in Individuals of Han Chinese and European Ancestries. JAMA Psychiatry. 2021;78(3):248–249. doi:10.1001/jamapsychiatry.2020.3639
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