In 2020, there were approximately 60 000 overdose deaths involving synthetic opioids in the US.1 Illegally produced fentanyl entered the heroin supply, but there are increasing reports of mixtures containing stimulants or nonopioids.2 Coingestion of opioids, especially highly potent fentanyls, with benzodiazepines increases risk of death.3
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Pardo B. Insights Into Mixing Fentanyl and Benzodiazepines From Canadian Drug Seizures. JAMA Psychiatry. 2022;79(1):81–83. doi:10.1001/jamapsychiatry.2021.3292
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