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Comment & Response
November 24, 2021

Limitations in Research on Maintenance Treatment for Individuals With Schizophrenia

Author Affiliations
  • 1Department of Psychiatry Aabenraa, Mental Health Services Region of Southern Denmark, Aabenraa, Denmark
  • 2Division of Psychology and Mental Health, School of Health Sciences, University of Manchester, Manchester, United Kingdom
  • 3Department of Psychiatry, Zucker Hillside Hospital, Glen Oaks, New York
JAMA Psychiatry. 2022;79(1):85-86. doi:10.1001/jamapsychiatry.2021.3452

To the Editor Relapse prevention is paramount in managing schizophrenia.1 Leucht et al2 conducted a meta-analysis of randomized clinical trials comparing the association between different antipsychotic maintenance doses and risk of relapse and rehospitalization in individuals with schizophrenia by generating efficacy-related dose-response curves. Prevention of relapse and rehospitalization increased with up to 5 mg/d risperidone equivalent. Higher doses conferred little further advantage for reducing relapse or rehospitalization, but were associated with higher intolerability-related dropout rates.

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