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Comment & Response
November 24, 2021

Limitations in Research on Maintenance Treatment for Individuals With Schizophrenia

Author Affiliations
  • 1Research and Development, Goodmayes Hospital, North East London National Health Service Foundation Trust, Goodmayes, Ilford, United Kingdom
  • 2Camden and Islington NHS Foundation Trust, London, United Kingdom
  • 3Pharmacy Department, South London and Maudsley National Health Service Foundation Trust, London, United Kingdom
JAMA Psychiatry. 2022;79(1):83-85. doi:10.1001/jamapsychiatry.2021.3400

To the Editor We appreciate the clinical value of the dose-response meta-analysis performed by Leucht and colleagues.1 The interpretation provided was that doses above 5 mg/d risperidone equivalent do not provide additional protection against relapse, while the risk of relapse increases rapidly (and apparently hyperbolically) for doses less than 2.5 mg/d risperidone equivalent.

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