To the Editor Van Lieshout and colleagues1 conducted a randomized clinical trial of an online 1-day cognitive behavioral therapy workshop vs waiting list in a population at risk of postpartum depression and evaluated the effect using the Edinburgh Postnatal Depression Scale, a patient-reported outcome measure of depressive symptom severity. Using linear mixed models (LMM) with restricted maximum likelihood estimation, they showed statistically significant group × time interactions with standard deviations were associated with Edinburgh Postnatal Depression Scale score (B = −2.94, SE = 8.67; P < .001). However, we have some concerns about the imputation methods for missing data used in this study.
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Toyomoto R, Funada S, Furukawa TA. Some Concerns About Imputation Methods for Missing Data. JAMA Psychiatry. 2022;79(3):270. doi:10.1001/jamapsychiatry.2021.3894
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