To the Editor We read with great interest the article by Köhler-Forsberg et al,1 which found that lithium was associated with a dose-dependent decrease in risk of osteoporosis in patients with bipolar disorder. Fractures are a major concern of patients and are associated with nearly all psychotropic medications2 as well as bipolar affective disorder itself.3 Lithium is an efficacious treatment of bipolar affective disorder and is already underused, according to many experts.4 This study provides a signal for another unique benefit with lithium relative to other mood stabilizers (and even other classes of psychotropic medications like benzodiazepines).
Houle J, Schweitzer L, Greenway KT. Complex Interaction of Lithium With Kidney and Bone Health. JAMA Psychiatry. 2022;79(9):936. doi:10.1001/jamapsychiatry.2022.1749
Artificial Intelligence Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.