Ketamine is a dissociative anesthetic that has been used in medicine for a half century, with recent trials demonstrating efficacy of esketamine (an enantiomer of ketamine) for treatment-resistant depression.1 In 2019, the US Food and Drug Administration approved the use of esketamine to treat this condition, although off-label use of racemic ketamine is now common.2 It is unclear whether extensive media coverage about the therapeutic benefits of ketamine and esketamine has influenced nonmedical or recreational use. In this cross-sectional study, we investigated seizures of illicit ketamine in the US from 2017 through 2022 as a measure of availability of ketamine for nonmedical use.