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Letters to the Editor
June 2000

Recurrent Depression and Stressful Life Events

Author Affiliations

Copyright 2000 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2000

Arch Gen Psychiatry. 2000;57(6):617-618. doi:

In reply

Persaud raises the issue of generation of life events as a crucial pathogenetic mechanism that may be favorably affected by psychotherapeutic strategies. Depression does seem to generate negative life events1,2; however, there is limited support for their etiological role in recurrent depression.1 The interaction between these events and residual symptoms should thus be considered. Hammen et al,3 in a longitudinal study, found that nonsymptomatic persons were relatively resistant to onset of depression even when exposed to high-impact stressful events, whereas those who were symptomatic continued to have both more depression and more high-impact events over time.