Persaud raises the issue of generation of life events as a crucial pathogenetic mechanism that may be favorably affected by psychotherapeutic strategies. Depression does seem to generate negative life events1,2; however, there is limited support for their etiological role in recurrent depression.1 The interaction between these events and residual symptoms should thus be considered. Hammen et al,3 in a longitudinal study, found that nonsymptomatic persons were relatively resistant to onset of depression even when exposed to high-impact stressful events, whereas those who were symptomatic continued to have both more depression and more high-impact events over time.
Giovanni A. Fava, Chiara Rafanelli. Recurrent Depression and Stressful Life Events. Arch Gen Psychiatry. 2000;57(6):617–618. doi: