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Letters to the Editor
July 2000

The Effects of Olive Oil on ω3 Fatty Acids and Mood Disorders

Arch Gen Psychiatry. 2000;57(7):715. doi:

We read with interest the article by Stoll et al1 on the benefits of ω3 fatty acids on the short-term course of illness in bipolar disorder. The treatment group in this trial received the ω3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid. The results are therefore consistent with the membrane phospholipid model of Horrobin,2 dating from more than 20 years ago, and with the finding by both Peet and colleagues3,4 and Maes and colleagues5 of depletion of ω3 polyunsaturated fatty acid levels (particularly docosahexaenoic acid) in erythrocyte membranes of patients with depressive disorder; indeed, the first group has also found that severity of unipolar depression negatively correlates with both erythrocyte membrane ω3 polyunsaturated fatty acid levels and dietary intake of these fatty acids.6

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