Fluvoxamine maleate increases early morning concentrations of melatonin in humans.1,2 The serotonin reuptake inhibitor was therefore assumed to enhance the melatonin production by providing a precursor surplus of serotonin. Alternatively, fluvoxamine might inhibit the melatonin metabolism. The following case report strongly supports the second hypothesis.
Grözinger M, Härtter S, Wang X, Röschke J, Hiemke C, Rose D. Fluvoxamine Strongly Inhibits Melatonin Metabolism in a Patient With Low-Amplitude Melatonin Profile. Arch Gen Psychiatry. 2000;57(8):812–813. doi:10.1001/archpsyc.57.8.812
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