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Letters to the Editor
November 2000

Treatment of Atypical Depression With Cognitive Therapy or Phenelzine

Arch Gen Psychiatry. 2000;57(11):1084-1085. doi:

In reply

In our article,1 we reported results from a double-blind, placebo-controlled, randomized clinical trial comparing the efficacy of cognitive therapy and clinical management plus either phenelzine or pill placebo in reducing depressive symptoms of adult outpatients with DSM-III-R major depressive disorder with atypical features, which were assessed using the Atypical Depression Diagnostic Scale (ADDS) (J. W. Stewart, MD, written communication, October 20, 1988, and March 20, 1990). Using an intention-to-treat sample (N = 108) and a 21-item Hamilton Rating Scale for Depression (HRSD-212) score less than or equal to 9), the response rates after cognitive therapy (58%) and phenelzine (58%) were significantly greater than after pill placebo (28%).

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