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Letters to the Editor
March 2001

Cognitive Impairment With Chronic Disease in Depression and Mortality—Reply

Arch Gen Psychiatry. 2001;58(3):307. doi:

In reply

Our recent article1 describes an increased risk of death for older men with minor depression and for older men and women with major depression. Various health and behavioral risk factors could not explain these increased risks. As Ms Gledhill correctly points out, cognitive impairment was ignored as a potential confounding variable. Since cognitive impairment has been shown to be associated with increased mortality2 as well as with depression,3,4 this omission may have caused bias. We conducted some additional analyses to address this issue.