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Letters to the Editor
April 2001

Is Prefrontal Cortex Thinning Specific for Antisocial Personality Disorder?—Reply

Arch Gen Psychiatry. 2001;58(4):402-403. doi:

In reply

We previously reported that 21 individuals with APD were found to have a reduction in prefrontal gray matter volumes compared with normal controls, psychiatric controls, and substance/alcohol–dependent controls.1 As Seifritz et al point out, the APD group had significantly higher rates of cocaine dependence than the substance-dependent control group (66.7% vs 30.8%). This appropriately raises the question as to whether the volume reduction in prefrontal gray matter is due to cocaine dependence.