We recently reported that longitudinal measures of cortisol and aggression were inversely correlated and that low cortisol levels were correlated with early onset of aggression.1 We hesitated to speculate on mechanisms underlying these associations because of the bidirectional possibilities and the many degrees of freedom within the hypothalamic-pituitary-adrenal (HPA) axis.
McBurnett K. Low Salivary Cortisol Levels and Aggressive Behavior—Reply. Arch Gen Psychiatry. 2001;58(5):514–515. doi:
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