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Letters to the Editor
March 2002

Acute Tryptophan Depletion in Schizophrenic Patients Treated With Clozapine

Arch Gen Psychiatry. 2002;59(3):291-292. doi:

There are data in support of an important role for serotonin (5-HT) in the pathophysiology of schizophrenia.1 Atypical antipsychotic drugs exhibit an increased ratio of 5-HT2A to dopamine D2 receptor–binding affinities as compared with typical agents, which may explain the improved efficacy and adverse effect profiles of the of the former.1 Previous investigations of 5-HT systems via acute tryptophan depletion (ATD) in psychotically ill individuals have involved subjects taking typical antipsychotics.2,3 Here, we describe the effects of ATD in clozapine-maintained individuals using a previously described, randomized, double-blind, placebo-controlled, counter-balanced ATD paradigm.4

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