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Letters to the Editor
August 2007

First- vs Second-Generation Antipsychotic Drugs in Schizophrenia

Arch Gen Psychiatry. 2007;64(8):978-979. doi:10.1001/archpsyc.64.8.978-b

The Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS 1)1 found that, in patients with schizophrenia whose medication was changed for clinical reasons, first (FGA)- and second (SGA)-generation antipsychotics were associated with comparable 1-year outcomes on measures of clinical improvement, adverse effects, quality of life, and costs of care. We have several concerns about the study:

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