We read with interest the important meta-analysis of brain volumes in unaffected first-degree relatives of patients with schizophrenia by Boos and colleagues.1 Given the highly influential status of meta-analysis in the hierarchy of evidence, methodological rigor in carrying out a meta-analysis is paramount. However, we note several apparent errors and question the authors' conclusion that brain abnormalities in such relatives are “most pronounced in the hippocampus.”
McDonald C, Dineen B, Hallahan B. Meta-analysis of Brain Volumes in Unaffected First-Degree Relatives of Patients With Schizophrenia Overemphasizes Hippocampal Deficits. Arch Gen Psychiatry. 2008;65(5):603–604. doi:10.1001/archpsyc.65.5.603
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