Dr Papadopoulos raises some interesting and pertinent points. In our study, we did not take into account an individual's history of exposure to sunlight.1 Whether our depressed cohort was less exposed to sunlight compared with healthy subjects because of limited outdoor activities remains problematic. If so, this might be expected to lower their brain serotonin turnover.2
Barton DA, Esler MD, Lambert GW. Season as a Possible Confounding Factor in Reduced Brain Serotonin Turnover Following Selective Serotonin Reuptake Inhibitor Therapy—Reply. Arch Gen Psychiatry. 2008;65(10):1225. doi:10.1001/archpsyc.65.10.1225-a
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