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Original Article
January 2009

Distinct Effects of Δ9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing

Author Affiliations

Author Affiliations: Section of Neuroimaging (Drs Fusar-Poli, Crippa, Bhattacharyy, Borgwardt, Allen, Martin-Santos, Seal, O’Carrol, Atakan, and McGuire) and Cognitive Neuropsychiatry (Dr Surguladze), Division of Psychological Medicine, Institute of Psychiatry, King's College London, London, England; Department of Applied and Psychobehavioural Health Sciences, University of Pavia, Pavia, Italy (Dr Fusar-Poli); Department of Neurology, Psychiatry, and Medical Psychology, Faculty of Medicine of Ribeirão Preto, University of Sao Paulo, Sao Paulo, Brazil (Drs Crippa and Zuardi); Psychiatric Outpatient Department, University Hospital Basel, Basel, Switzerland (Dr Borgwardt); and Melbourne Neuropsychiatry Centre, The University of Melbourne, Melbourne, Australia (Dr Seal).

Arch Gen Psychiatry. 2009;66(1):95-105. doi:10.1001/archgenpsychiatry.2008.519
Abstract

Context  Cannabis use can both increase and reduce anxiety in humans. The neurophysiological substrates of these effects are unknown.

Objective  To investigate the effects of 2 main psychoactive constituents of Cannabis sativa (Δ9-tetrahydrocannabinol [Δ9-THC] and cannabidiol [CBD]) on regional brain function during emotional processing.

Design  Subjects were studied on 3 separate occasions using an event-related functional magnetic resonance imaging paradigm while viewing faces that implicitly elicited different levels of anxiety. Each scanning session was preceded by the ingestion of either 10 mg of Δ9-THC, 600 mg of CBD, or a placebo in a double-blind, randomized, placebo-controlled design.

Participants  Fifteen healthy, English-native, right-handed men who had used cannabis 15 times or less in their life.

Main Outcome Measures  Regional brain activation (blood oxygenation level–dependent response), electrodermal activity (skin conductance response [SCR]), and objective and subjective ratings of anxiety.

Results  Δ9-Tetrahydrocannabinol increased anxiety, as well as levels of intoxication, sedation, and psychotic symptoms, whereas there was a trend for a reduction in anxiety following administration of CBD. The number of SCR fluctuations during the processing of intensely fearful faces increased following administration of Δ9-THC but decreased following administration of CBD. Cannabidiol attenuated the blood oxygenation level–dependent signal in the amygdala and the anterior and posterior cingulate cortex while subjects were processing intensely fearful faces, and its suppression of the amygdalar and anterior cingulate responses was correlated with the concurrent reduction in SCR fluctuations. Δ9-Tetrahydrocannabinol mainly modulated activation in frontal and parietal areas.

Conclusions  Δ9-Tetrahydrocannabinol and CBD had clearly distinct effects on the neural, electrodermal, and symptomatic response to fearful faces. The effects of CBD on activation in limbic and paralimbic regions may contribute to its ability to reduce autonomic arousal and subjective anxiety, whereas the anxiogenic effects of Δ9-THC may be related to effects in other brain regions.

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