The neurophysiologist has become interested in exploring the possibility that functional disorders may be basically a disturbance in the interaction of neurons, particularly the neurons of that complex network composing the brain. These neurons need not be structurally abnormal. Instead, they can be normal neurons that have learned to fire off in spatiotemporal patterns detrimental to the organism. Neurons do affect each other, and there are indications that activity within the motor portion of the nervous system can have pronounced effects on activity elsewhere in the nervous system (Refs. 2, 13, 15, 17, 18, 20, 22, 23, 24, 27, 30, 32, 38, 41, 50, 51, 56, 66, 67). On the basis of such studies, as well as from other findings, numerous investigators have come to believe that motor activity is more than just an end-product of psychic activity (Refs. 3, 5, 8, 9, 14, 21, 29,
WHATMORE GB, ELLIS RM. Some Neurophysiologic Aspects of Depressed StatesAn Electromyographic Study. JAMA Psychiatry. 1959;1(1):70–80. doi:10.1001/archpsyc.1959.03590010086010
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