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January 1960

Effects of LSD-25 and Amphetamine on a Running Response in the Rat

Author Affiliations

Veterans Administration Hospital, Coatsville, Pa., and the Department of Psychiatry, University of Pennsylvania School of Medicine.

AMA Arch Gen Psychiatry. 1960;2(1):104-109. doi:10.1001/archpsyc.1960.03590070106013

After injection of d-lysergic acid diethylamide (LSD-25) in the rat, the animal shows symptoms of autonomic effects, such as profuse salivation, urination, and defecation. There is some indication that the somatic nervous system is also involved, since the animal exhibits hyperactivity in the first few minutes after injection, while after three to five minutes there is a tendency for all four legs to flex and the abdomen touches the floor. At this point the animal may remain motionless for long periods if permitted to stay in its living cage undisturbed. These symptoms have been observed by Winter and Flataker1 and also by me. Winter and Flataker, in the same study, also observed that for rats trained to climb a rope for food reinforcement, climbing times were increased as a function of dosage levels. At the height of the drug effect some of the rats did not