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May 1960

Effects of Triiodothyronine in Schizophrenic Patients: Correlations of Changes in Basal Metabolism with Urinary Creatine and Cholesterol and Tocopherol Levels in the Blood

Author Affiliations

Elgin, Ill.
Biochemical Research Laboratory, Elgin State Hospital.

AMA Arch Gen Psychiatry. 1960;2(5):528-533. doi:10.1001/archpsyc.1960.03590110052006

In a previous paper, the effects of triiodothyronine on the psychiatric status, serum copper, basal metabolism, erythrocyte sedimentation rate, and C-reactive protein in schizophrenic subjects were described.1 Changes in serum cholesterol, plasma tocopherol, and urinary creatine-to-creatinine ratio with respect to the basal metabolic rate (B. M. R.) in chronic schizophrenic subjects treated with triiodothyronine are reported here. At present, there is no reasonable evidence to indicate that metabolic data from these subjects would be different from those obtained from nonschizophrenic subjects. Elevated creatine excretion and B. M. R. and decreased creatinine in the urine, as well as corresponding changes in the serum level of these substances, have been observed in cases of hyperthyroidism.2,4 Both serum cholesterol and tocopherol levels are increased in clinical states of hypothyroidism, and there appears to be an indirect relationship between B. M. R. and blood cholesterol.5,6

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