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August 1960

Lysergic Acid Diethylamide (LSD) and JB 318: A Comparison of Two Hallucinogens: II. An Exploratory Study

Author Affiliations

From the Departments of Preventive Medicine and Psychiatry, University of Illinois College of Medicine, and the Department of Psychology, Roosevelt University.

Arch Gen Psychiatry. 1960;3(2):176-187. doi:10.1001/archpsyc.1960.01710020060008

Introduction  The first article in this series contained a description of the purposes and methodology of the study.1 The aims of the research as stated therein were twofold: (1) to define the effects of both drugs in terms of psychometric tests, and (2) to compare the new hallucinogen, JB 318 (N-ethyl-3-piperidyl benzilate) with LSD (lysergic acid diethylamide), a drug that has become a sort of standard of reference in the area. Ten carefully screened medical student volunteers participated in the double-blind, counterbalanced design experiment. They ingested 100μg. of LSD on one occasion and 15 mg. of JB 318 on the other. The interval between drug experiments was five to eight weeks. Psychiatric interviews, tape recorded and rated, and bodily measurements were carried out before and at predetermined intervals after the administration of each drug.1 The Minnesota Multiphasic Personality Inventory (MMPI), Rorschach test, Jarvik

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