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February 1961

Disturbed Serum Proteins in Chronic Psychosis: Serological, Medical, and Psychiatric Correlations

Author Affiliations

The Langley Porter Neuropsychiatric Institute and The Rheumatic Disease Group of the Department of Medicine of the University of California, San Francisco.

Arch Gen Psychiatry. 1961;4(2):154-159. doi:10.1001/archpsyc.1961.01710080050008

Introduction  In a recent review3 G. F. Solomon and I found the mean incidence of psychosis in systemic lupus erythematosus (S.L.E.) to be 22%. We also found that in several reports, patients had had a psychosis for months or years prior to the onset of the systemic features of lupus erythematosus. In the case we reported the patient had had a psychosis continuously for 16 years before S.L.E. was diagnosed. We felt that in some cases the evidence suggested that psychosis might be the first, and often even sole, manifestation of S.L.E. We wondered about the incidence of S.L.E. in a chronically psychotic population and decided to screen such a population for the presence of the so-called lupus factor in their serum by means of the nucleoprotein latex agglutination test.In contrast to S.L.E., rheumatoid arthritis (R.A.) has been thought to be very rarely associated with psychosis.

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