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November 1961

Studies of Salivation in Depression: II. Physiological Differentiation of Reactive and Endogenous Depression

Author Affiliations

Massachusetts Mental Health Center and Department of Psychiatry, Harvard Medical School.

Arch Gen Psychiatry. 1961;5(5):472-477. doi:10.1001/archpsyc.1961.01710170050006

It has been pointed out elsewhere1 that objective clinical study of both psychological and somatic manifestations of mental illness are necessary to delineate diseases as they occur in nature and not as they are necessarily classified by man. In the psychophysiological states known as depression, psychic and somatic disturbances are more complicated than the psychomotor retardation frequently assumed.2 Though direct observation of physiological changes in depressed states has been reported, psychopathology of depression has received much more emphasis and study.

Renewed interest in specific physiological changes associated with depression has occurred with the reexploration of disturbances of salivation in depressed patients. Twenty years ago the pioneering work of Strongin and Hinsie3 and Winsor4,5 focused on the collection of saliva from the parotid gland using the Lashley suction cup technique. It was shown that patients with depression salivate

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