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July 1962

LSD and JB 318: A Comparison of Two Hallucinogens: III. Qualitative Analysis and Summary of Findings

Author Affiliations

From the Departments of Preventive Medicine and Psychiatry, University of Illinois College of Medicine.

Arch Gen Psychiatry. 1962;7(1):39-45. doi:10.1001/archpsyc.1962.01720010041006

Introduction  This is the third and last of a series of papers that compare the effects of lysergic acid diethylamide (LSD) and JB 318 (N-ethyl-3-piperidyl benzilate). The first 2 articles described and compared in quantitative terms the effects of these 2 drugs on several psychological tests.1,2 They may be summarized very briefly. LSD 100μg. and JB 318 15 mg. were administered orally to 10 medical students in a counterbalanced design. While JB 318 induced more hallucinations, LSD administration was oftener followed by changes in affect and body image. Both drugs significantly elevated the F (Validity), D (Depression), Pt (Psychasthenia), and Sc (Schizophrenia) scale scores among the classical Minnesota Multiphasic Personality Inventory (MMPI) scales. LSD alone significantly increased the Ma (Hypomania) and the Wynne Neuroticism scale scores. JB 318 alone increased the scores on the Hs (Hypochondriasis) and L (Lie) scales.Subjects whose predrug

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