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July 1963

Stress-Responsive Indole Substance

Arch Gen Psychiatry. 1963;9(1):89-95. doi:10.1001/archpsyc.1963.01720130091011

Previous work reported from our laboratory1-3 has indicated that there were various physiological influences on indole compound excretion, notably, diurnal variability, urine volume, and diet. In addition, a "stress-responsive indole substance" (SRIS) has been seen after extraction and chromatography; this substance appeared in the urine at the same time as the peak of 17-hydroxycorticosteroid excretion following corticotropin activation of the adrenal gland. The present report concerns a systematic attempt to verify the 17-hydroxycorticosteroid-SRIS relationship and, in addition, to study the effect of controlled diet, tryptophan load, and tryptophan load and corticotropin combination on indole excretion. It appears that the SRIS is of particular interest in that we have recently demonstrated increases and decreases of plasma 17-hydroxycorticosteroid levels in man from stimulation in the amygdala and hippocampus,4 respectively. These findings, taken in combination with the recent reports of the temporal lobe