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April 1964

The Bone Marrow in Schizophrenia

Author Affiliations

From the Departments of Psychiatry and Medicine, University of California School of Medicine.

Arch Gen Psychiatry. 1964;10(4):414-419. doi:10.1001/archpsyc.1964.01720220092014

The purpose of this paper is (1) to present additional hematological abnormalities seen in studies of bone marrow of schizophrenic patients; (2) to give evidence for the genealogy of the abnormal cells which have been described in the peripheral blood of schizophrenic patients1; and (3) to suggest that these abnormal cells may be related to the abnormal blood proteins found in psychiatric patients.2 Elsewhere we have described the abnormal white blood cells in schizophrenia as falling into three main types: the first representing abnormal lymphocytes; the second seeming to belong to the reticulum cell series; and the least numerous, the third type, being multinucleated giant cells.1 Kamp found that in comparison to normal the nucleus of the lymphocyte was deeper staining and the chromatin lacked an organized pattern.3

Materials and Methods

Patients.—We studied seven male, chronic

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