WITHIN recent years it has been observed repeatedly that animals6,10,11 and humans14,16 may show marked emotional reactions to novel environmental changes as reflected in substantial plasma and urinary 17-hydroxycorticosteroid (17-OHCS) elevations. The general consistency of these findings has suggested that transfer to new and unfamiliar environments might be a useful experimental measure for predictably eliciting emotional arousal in human subjects in psychophysiological or psychosomatic studies. The present investigation is concerned with measurement of the 17-OHCS responses in several groups of normal young adults to hospital admission under relatively standardized conditions. A primary objective is to evaluate the practicability of using hospital admission as an experimental means for eliciting emotional or psychoendocrine disturbance, with an interest not only in the magnitudé of mean 17-OHCS response, but also in the extent of group and individual differences. If substantial psychoendocrine responses do occur when normal
MASON JW, SACHAR EJ, FISHMAN JR, HAMBURG DA, HANDLON JH. Corticosteroid Responses to Hospital Admission. Arch Gen Psychiatry. 1965;13(1):1–8. doi:10.1001/archpsyc.1965.01730010003001
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