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November 1965

The Action of Neuroleptic Drugs.

Arch Gen Psychiatry. 1965;13(5):479-480. doi:10.1001/archpsyc.1965.01730050093020

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Numerous drugs have been and are being used by psychiatrists for the treatment of various psychiatric disorders. The authors discuss one group, the neuroleptics, which includes the phenothiazines, rauwolfia alkaloids, butyrophenones, and thiaxanthenes. The term "neuroleptic" was introduced by Delay in 1954 and is based on Janet's term "psycholepsy" to denote a fall in psychological tension. This is desirable for excited paranoid schizophrenics and excited manics.

Dr. Haase has been studying neuroleptics since 1953 and this book is based on his numerous articles. The material in many chapters is therefore repetitious. His thesis is "that the appearance, at least temporarily, of fine motor extrapyramidal hypokinesia is associated conditio sine qua non with the antipsychotic action of these drugs." The therapeutic effectiveness is produced by a "reduction of the extrapyramidal psychokinetic conation," thereby allowing the organism's tendency to self-recovery to function, and the patient is then

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