IN THE FIRST part of this longitudinal study,3,6 a reduced intake of methionine and tryptophan failed to affect schizophrenic behavior conclusively. During this period of seven months of continuously controlled tryptophan intake we found that increases of urinary indoles occurred independently of tryptophan intake when schizophrenic symptoms in some of the patients grew worse spontaneously. The excretions of catecholamines34 and urinary steroid hormones28 were also elevated with accompanying motor hyperactivity, increased tension and anxiety.
The objective of the second part of this investigation was to study the behavioral responses to increases of methionine and tryptophan as well as that of methionine given together with a monoamine oxidase inhibitor (MAOI). Both improvement and worsening of behavior have been reported for normal, schizophrenic, and depressed subjects.9,14,27,32 It appeared, therefore, of interest to study urinary excretion patterns in relation to amino acid intake and accompanying
BERLET HH, MATSUMOTO K, PSCHEIDT GR, SPAIDE J, BULL C, HIMWICH HE. Biochemical Correlates of Behavior in Schizophrenic Patients: Schizophrenic Patients Receiving Tryptophan and Methionine or Methionine Together With a Monoamine Oxidase Inhibitor. Arch Gen Psychiatry. 1965;13(6):521–531. doi:10.1001/archpsyc.1965.01730060039006
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: