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Article
October 1966

Serum Aminopeptidase and Beta-Glucuronidase ActivitiesSerum aminopeptidase and Beta-Glucuronidase Activities in Patients With Mental Disease

Author Affiliations

BOSTON
From the Yamins Laboratory for Surgical Research, Beth Israel Hospital, the Department of Surgery, Beth Israel Hospital, and Harvard Medical School, Boston, and the Laboratory of Clinical Physiology, McLean Hospital, Belmont, Mass.
Dr. Goldbarg died Sept 23, 1963.

Arch Gen Psychiatry. 1966;15(4):341-343. doi:10.1001/archpsyc.1966.01730160005002
Abstract

THE AVAILABILITY of methods of estimating the serum activities of a number of enzymes has permitted the study of these functions in patients with mental disorders. To date no specific abnormalities have been found, but abnormalities caused by hepatic dysfunction owing to alcohol, by starvation, and by hepatotoxic drugs have been noted by many authors. However, few data on the serum aminopeptidase * or β-glucuronidase activity in patients in mental hospitals have been reported.1 This is a serious lack because several important psychotropic drugs are excreted largely as glucuronides,2-5 and some may produce a hepatic injury. The serum activities of these enzymes are abnormal in patients with liver disease6,7 and these abnormalities have been found particularly useful in the detection of hepatic disorders in anicteric patients.8

Material and Methods  Studies were made on 105 patients aged 13 to 93 years; 68 of them were

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