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October 1966

A Heterophil Hemolysin in Human Blood: I. Distribution in Schizophrenics and Nonschizophrenics

Author Affiliations

From the Research Division, Central Islip (New York) State Hospital.

Arch Gen Psychiatry. 1966;15(4):373-377. doi:10.1001/archpsyc.1966.01730160037007

DESPITE increasingly intensive research over a period of 70 years for a "biochemical lesion" in schizophrenias, none of the many reported has been found to be both reproducible and relevant.1,2 The very recent demonstration of the presence of 3,4-dimethylphenylethylamine in urine3 may prove to be the first exception; the present report is submitted concerning a potential second.

In 1947 Sjovall4 reported that mice who died after intravenous injection of serum of schizophrenics had hemoglobinuria. This hemoglobinuria could be prevented by heating serum to 56 C for 30 minutes without, however, destroying toxicity. Other authors, earlier, had reported a decrease in toxicity upon heating serum.5,6 No one seems to have connected these observations to the long-studied phenomenon of heterophil antibodies,7,8 although lethal action of heterologous serum injected into veins of another species had been supposed to be due to antibody-antigen

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