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April 1967

Stress: Psychophysiological and Cognitive Indices in an Acute Double-Blind Study With Hydroxyzine in Psychiatric Patients

Author Affiliations

Oklahoma City
From the Behavioral Science Laboratories, Veterans Administration Hospital, Oklahoma City, and the Department of Psychiatry, Neurology, and the Behavioral Sciences, University of Oklahoma School of Medicine.

Arch Gen Psychiatry. 1967;16(4):471-478. doi:10.1001/archpsyc.1967.01730220083012

THIS STUDY was designed to investigate the effects of a psychoactive drug, hydroxyzine, on information processing capability and levels of Central Nervous System (CNS) activation of psychiatric patients undergoing physical and cognitive stress. It has been shown by a number of investigators that, in addition to being a Psychotropic agent, hydroxyzine has been useful as an analgesic,1 as well as in alcoholism,2 obstetrics,3,4 treatment of allergies,5 oral surgery,6 reducing tension in children,7 and senile patients.8 It was also found to be an effective serotonin antagonist,9 and to have anticholinergic and antihistaminic properties.1 Electrophysiological studies reveal that conduction in frogs' sciatic nerves was blocked and muscle responses were progressively decreased and eventually completely disappeared with the administration of hydroxyzine.10 In relation to the learning process, there is evidence that hydroyzine was effective in suppressing