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November 1967

Long Lasting Effects of LSD on Normals

Author Affiliations

Los Angeles
From the Department of Psychology, University of Southern California, Los Angeles.

Arch Gen Psychiatry. 1967;17(5):521-532. doi:10.1001/archpsyc.1967.01730290009002

THIS IS A report of a study designed to measure personality, attitude, value, interest, and performance changes resulting from the administration of LSD to normals. Several investigators using LSD with humans in nontherapy experiments have observed that some of their subjects report various lasting effects attributable to the drug experience.1,2 In addition, the recent controversy over the nonmedical use of LSD has given rise to numerous claims and counterclaims in this regard. We have previously reported on a pilot study in which tests of anxiety, attitudes, and creativity were given to 15 subjects prior to, and one week following, a single 200μg LSD session. Some significant changes in the anxiety and attitude tests were observed, but none were found for the creativity measures.3

The assessment of lasting effects of hallucinogens involves extradrug variables to a greater extent than do most drug studies.