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This publication is a compilation of the papers and discussions presented at a conference held at Princeton, New Jersey, November 1965, under the auspices of the National Institute of Neurological Diseases and Blindness. Unlike many such symposia, a serious attempt was made by the essayists to maintain a unified central thesis. The organizers of the conference should be complimented also for allocating more than 50% of the time available to open discussion. This, together with the fact that papers were limited to 18 and participants to approximately 60, resulted in a conference relatively free from discrete presentations of previously published work with little if any bearing on the central topic. The foregoing comments should not be construed as suggesting that the topics covered were restricted. To the contrary, the presentations and discussions were remarkably free-ranging. This can best be appreciated