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November 1968

Anti-Rabbit Heterophile Hemolysin and Agglutinin in Human Serum: Failure to Corroborate Previous Observations on Schizophrenics

Author Affiliations

New York
From the Research Division, Central Islip State Hospital, Long Island, NY.

Arch Gen Psychiatry. 1968;19(5):616-618. doi:10.1001/archpsyc.1968.01740110104013

IN AN EARLIER publication in the ARCHIVES OF GENERAL PSYCHIATRY1 we reported the occurrence in human serum of an antibody which hemolyses rabbit erythrocytes. We reported that when a large number of persons, including patients at this hospital, patients in general medical-surgical hospitals, and healthy controls, were studied, a bimodal distribution of hemolysin level was found. Over 70% of schizophrenics but less than 25% of controls gave sera with titres above the low point of the distribution. During two years of work on this system, these findings were extended, with a final N of 616 and a χ2 of 111 differentiating schizophrenics from all other groups.

Two other laboratories were unable to confirm our observations. At a third laboratory, differences in hemolysin titre were found to be related to a difference in time of mixing serum and erythrocytes and in the subsequent

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