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December 1968

Chromosome Studies in Patients With Affective Disorder (Manic-Depressive Illness)

Author Affiliations

St. Louis
From the departments of psychiatry and obstetrics and gynecology, Washington University School of Medicine, St. Louis. Dr. Sherman is currently at the Sinai Hospital, Detroit.

Arch Gen Psychiatry. 1968;19(6):751-752. doi:10.1001/archpsyc.1968.01740120111015

CONSIDERABLE evidence points to a genetically determined predisposition to affective disorder. In Kallman's study, the concordance rate for monozygotic twins was 100%; for dizygotic twins, 25.5%; for full siblings, 22.7%; for half siblings, 16.7%; and for parents of probands, 23.4%.1 Winokur and Pitts2,3 have presented data showing that siblings and parents of affective disorder probands have a higher rate of affective disorder themselves than the siblings and parents of control subjects.

Chromosome studies have been reported on schizophrenics4,5 and other groups of psychiatric patients,6 but not on a group of manic-depressive patients.

Materials and Methods  All of the patients with affective disorder were adults and met the criteria of Cassidy et al7 for the diagnosis of manic-depressive illness.During the first phase of this project, 13 patients with affective disorder were studied. Of these, ten patients had a positive family history

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