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February 1969

Study of Monozygotic Twins Discordant for SchizophreniaSome Biologic Variables (Lactate-Pyruvic Ratio; 3,4-Dimethoxyphenlethylamine; S19 Macroglobulin; Antirabbit Red Cell Hemagglutin; Protein Bound Iodine)

Author Affiliations

Bethesda, Md; Detroit; New York; Central Islip, NY
From the Section on Twin and Sibling Studies, Adult Psychiatry Branch, NIMH, Bethesda, Md (Drs. Stabenau, Pollin, and Mosher); the Lafayette Clinic, New York (Dr. Frohman); New York University School of Medicine, New York (Dr. Friedhoff); and Central Islip State Hospital, Central Islip, NY (Dr. Turner). Dr. Mosher is currently at the Center for Studies of Schizophrenic, Clinical Research Branch, Division of Extramural Research Programs, NIMH, Chevy Chase, Md.

Arch Gen Psychiatry. 1969;20(2):145-158. doi:10.1001/archpsyc.1969.01740140017002

A MULTIDISCIPLINARY study of pairs of monozygotic twins in which one has displayed schizophrenic symptomatology and the other has not is being conducted at the Clinical Center, National Institute of Mental Health (NIMH), Bethesda, Md.1-3 Investigation includes psychiatric, Psychologic, physiologic, and biochemical variables which are studied in each of the monozygotic (MZ) twins and both biologic parents. Previous papers have reported a number of the psychiatric and psychologic findings. This paper focuses on some of the biologic variables.

Frohman et al4,5 have reported a series of studies which suggested that individuals with a diagnosis of schizophrenia, as compared with nonschizophrenic controls, had a serum factor which produced higher lactate-pyruvate (L/P) ratios in an incubated chicken erythrocyte preparation. The work of Fessel et al6,7 indicated that psychotics, especially schizophrenics, had higher serum levels of S19 macroglobulins as compared to control subjects. Friedhoff and

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