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April 1969

All-Night Sleep Studies of Acute Schizophrenics

Author Affiliations

From the Department of Psychiatry, Harvard Medical School and the Massachusetts Mental Health Center, Boston. Dr. Wyatt is currently at the National Institute of Mental Health, Bethesda, Md.

Arch Gen Psychiatry. 1969;20(4):470-477. doi:10.1001/archpsyc.1969.01740160086012

THE relationship between sleep and schizophrenia, and particularly the dream state and schizophrenia, has long held the neuropsychiatrist's attention and interest. Kraepelin,1 Jackson,2 and Jung3 hypothesized around the turn of the century, that a similarity did indeed exist between the dream state and dementia praecox. Objective methods for studying sleep and dreaming, however, were lacking, and research in the borderland of sleep-schizophrenia remained in the realm of speculation. With the discovery by Aserinsky, Kleitman, and Dement4-6 in the early 1950's that through all-night electroencephalogram (EEG) recordings, sleep could be qualitatively separated into two distinct interdigitating phases—rapid eye movement (REM) sleep and slow wave sleep, the former being associated with a high percentage of dream recall—the sleepschizophrenia paradigm became subject for the first time to experimental scrutiny.

Most sleep studies with schizophrenics since then have focused on the REM state, comparing schizophrenics with their normal counterparts. The

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