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December 1969

Rabbit Erythrocyte Hemagglutinins in Schizophrenia

Author Affiliations

From the departments of microbiology and psychiatry, School of Medicine, State University of New York at Buffalo. Dr. Lang is now at the Department of Medical Microbiology, College of Medicine, Ohio State University, Columbus.

Arch Gen Psychiatry. 1969;21(6):665-672. doi:10.1001/archpsyc.1969.01740240025004

THERE are numerous reports of the presence of abnormal levels of various serum proteins in psychotic patients.1-4 Serum globulins have been examined for antibody to brain tissue and to other antigens.5-7 Presumably, these antibodies appear in the serum as a result of autoimmunization or from stimulation by foreign antigens. Elevated γglobulin levels may result also from an increase in antibodies that are normally present in human sera. Elevated titers of various hemagglutinins occur in certain diseases and have been an aid in diagnosis.8 About 98% of normal individuals have low levels of sheep hemagglutinins in their sera. As a result of serum sickness, Hodgkin's disease, leukemia, infectious mononucleosis, and a number of other illnesses, hemagglutinin levels may increase considerably. Cold hemagglutinins have been found in 95% of normal sera in low titer, and high titers are occasionally associated with primary atypical

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