THE USE of psychiatric rating scales for quantifying symptoms and signs is a recent methodologic refinement in behavioral-biochemical correlative investigations of psychiatric patients. Small-sample longitudinal studies, wherein the patient acts as his own control, have shown a number of interesting psychochemical and psychoendocrine correlations that were not evident with earlier cross-sectional sampling techniques.1-8 Also, multivariate analytic methods now permit both the recognition of intra-individual correlations and the generalization of these correlations into group patterns.9 In this paper are presented the results of multivariate analyses of changes over time of manifest psychopathology, quantified by a psychiatric rating scale, and multiple urine biochemical measures in manic-depressive patients. This study attempts to exploit the power of multivariate analytic techniques to elucidate the role of biochemical factors in manic-depressive illness.
In earlier reports studies of several biochemical measures in manic-depressive illness
Rubin LRT, Overall JE. Manifest Psychopathology and Urine Biochemical Measures: Multivariate Analyses in Manic-Depressive Illness. Arch Gen Psychiatry. 1970;22(1):45–57. doi:10.1001/archpsyc.1970.01740250047008
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