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January 1970

Manifest Psychopathology and Urine Biochemical Measures: Multivariate Analyses in Manic-Depressive Illness

Author Affiliations

San Diego, Calif; Galveston, Tex
From the Navy Medical Neuropsychiatric Research Unit ,San Diego, Calif, and the Department of Psychiatry, UCLA School of Medicine, Los Angeles (Dr. Rubin), and the Department of Neurology and Psychiatry, University of Texas Medical Branch, Galveston, Tex (Dr. Overall).

Arch Gen Psychiatry. 1970;22(1):45-57. doi:10.1001/archpsyc.1970.01740250047008

THE USE of psychiatric rating scales for quantifying symptoms and signs is a recent methodologic refinement in behavioral-biochemical correlative investigations of psychiatric patients. Small-sample longitudinal studies, wherein the patient acts as his own control, have shown a number of interesting psychochemical and psychoendocrine correlations that were not evident with earlier cross-sectional sampling techniques.1-8 Also, multivariate analytic methods now permit both the recognition of intra-individual correlations and the generalization of these correlations into group patterns.9 In this paper are presented the results of multivariate analyses of changes over time of manifest psychopathology, quantified by a psychiatric rating scale, and multiple urine biochemical measures in manic-depressive patients. This study attempts to exploit the power of multivariate analytic techniques to elucidate the role of biochemical factors in manic-depressive illness.

In earlier reports studies of several biochemical measures in manic-depressive illness