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November 1970

EEG-Averaged Evoked Response and Perceptual Variability in Schizophrenics

Author Affiliations

Washington DC; Bethesda, Md; San Jose, Calif
From the Laboratory of Clinical Psychopharmacology, Division of Special Mental Health Research, IR National Institute of Mental Health, St. Elizabeth's Hospital, Washington DC (Dr. Inderbitzin); the Laboratory of Psychology, National Institute of Mental Health, Bethesda, Md (Dr. Buchsbaum); and Agnews State Hospital, San Jose, Calif (Dr. Silverman).

Arch Gen Psychiatry. 1970;23(5):438-444. doi:10.1001/archpsyc.1970.01750050054008

PERCEPTUAL and cognitive studies of schizophrenic patients characteristically reveal great variability. Not only does the performance of schizophrenics on psychological tests typically cover a much broader response range than that of nonschizophrenics, but individual performance shows great variability across time.1 By selecting representatives of two schizophrenic subtypes as subjects for this study, we hoped to reduce interindividual variability, thus enabling ourselves to observe intraindividual variability more clearly. The two subtypes, nonparanoid long-term process and paranoid short-term reactive, have clinical characteristics often thought to be consistently associated with markedly different perceptual behavior patterns.1 To test the hypothesis that the two groups show contrasting perceptual patterns, two psychophysical tasks and an average evoked response (AER) measure were administered.

In previous researches, a correlation was demonstrated in normal waking-state subjects between reponsiveness on a kinesthetic figural aftereffects (KFA) procedure and responsiveness on an AER

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