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October 1971

Altered Tyrosine Daytime Plasma Levels in Endogenous Depressive Patients

Author Affiliations

Munich, West Germany
From the Neurochemistry Division, Max Planck Institute for Psychiatry, Munich, West Germany. Dr. Benkert is currently at the University of Munich.

Arch Gen Psychiatry. 1971;25(4):359-363. doi:10.1001/archpsyc.1971.01750160071013

The tyrosine plasma concentration of 38 endogenous depressives was compared with that of neurotic depressives, schizophrenics, and healthy controls at 8 AM, 11 AM, 2 PM, and 5 PM. The 8 AM tyrosine concentration was about equal in all groups, but there was a significant decrease of the tyrosine level at 11 AM in endogenous depressives, as compared with the other three groups. The possible causes and the consequences of this tyrosine decrease are discussed.