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December 1972

Plasma Androgens in Male Schizophrenics

Author Affiliations

Iowa City
From the Department of Psychiatry, University of Iowa College of Medicine, Iowa City (Dr. Hatfield) and the Lafayette Clinic and the Department of Psychiatry, Wayne State University School of Medicine, Detroit (Dr. Tourney).

Arch Gen Psychiatry. 1972;27(6):753-755. doi:10.1001/archpsyc.1972.01750300025004

Peripheral plasma androgen levels have been studied in control subjects, acute, chronic institutionalized, and chronic noninstitutionalized schizophrenic patients. The androgens determined included testosterone, dehydroandrosterone, and androstenedione. The schizophrenic groups did not show any significant difference from controls for plasma levels of testosterone and androstenedione. Both chronic schizophrenic groups have a significantly lower level of dehydroandrosterone. This change appears to be independent of age and institutionalization variables. Dehydroandrosterone is derived principally from the adrenal cortex and this suggests the possibility of reduced adrenal cortical functioning in chronic schizophrenia.