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December 1972

Contingent Negative Variation Amplitudes: Marihuana and Alcohol

Author Affiliations

Palo Alto, Calif
From the Department of Psychiatry, Stanford University School of Medicine and Palo Alto Veterans Administration Hospital, Palo Alto, Calif.

Arch Gen Psychiatry. 1972;27(6):809-811. doi:10.1001/archpsyc.1972.01750300071012

In a double-blind study, the amplitude of the contingent negative variation (CNV) was assessed in 12 normal men given placebo and quantified "social" doses of 1-δ9-transtetrahydrocannabinol (THC) and alcohol (ethyl alcohol). Using subjects as their own controls, it was found that THC selectively enhanced the amplitude as compared to placebo while alcohol depressed it.