Ten normal women were injected intravenously with lopremone (thyrotropin releasing hormone) and saline given one to four weeks apart in a double-blind study. After saline, somatic symptoms and mental changes were negligible. After lopremone, subjects experienced a variety of somatic symptoms, usually within a few minutes of injection.
Later they experienced relaxation, mild euphoria, and a sense of increased energy. Since correlation analyses showed that intensity of euphoria was not related to frequency of side-effects and was negatively related to magnitude of thyrotropin (thyroid stimulating hormone, TSH) response, euphoria presumably did not arise solely from suggestion or from thyroid stimulation.
Wilson IC, Prange AJ, Lara PP, Alltop LB, Stikeleather RA, Lipton MA. THR (Lopremone): Psychobiological Responses of Normal Women: I. Subjective Experiences. Arch Gen Psychiatry. 1973;29(1):15–21. doi:10.1001/archpsyc.1973.04200010006001
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