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July 1973

THR (Lopremone): Psychobiological Responses of Normal WomenI. Subjective Experiences

Arch Gen Psychiatry. 1973;29(1):15-21. doi:10.1001/archpsyc.1973.04200010006001

Ten normal women were injected intravenously with lopremone (thyrotropin releasing hormone) and saline given one to four weeks apart in a double-blind study. After saline, somatic symptoms and mental changes were negligible. After lopremone, subjects experienced a variety of somatic symptoms, usually within a few minutes of injection.

Later they experienced relaxation, mild euphoria, and a sense of increased energy. Since correlation analyses showed that intensity of euphoria was not related to frequency of side-effects and was negatively related to magnitude of thyrotropin (thyroid stimulating hormone, TSH) response, euphoria presumably did not arise solely from suggestion or from thyroid stimulation.