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July 1973

THR (Lopremone): Psychobiological Responses of Normal Women: II. Pituitary-Thyroid Responses

Author Affiliations

Chapel Hill, NC
From the Department of Psychiatry, Medical School and the Biological Sciences Research Center, University of North Carolina, Chapel Hill (Drs. Prange, Breese and Lipton); the Division of Research, North Carolina Mental Health Department, Raleigh (Drs. Wilson, Lara, and Alltop); and the Department of Medicine, Northwestern University Medical School, Chicago (Dr. Wilber).

Arch Gen Psychiatry. 1973;29(1):28-32. doi:10.1001/archpsyc.1973.04200010015002

Ten normal women were injected intravenously with lopremone (thyrotropin releasing hormone) and saline given one to four weeks apart. Lopremone injection caused a sharp rise in thyrotropin (thyroid stimulating hormone, TSH) levels with a return to near-base line levels in three hours. These TSH responses were slightly greater than those previously elicited in depressed women but the difference was statistically insignificant. After lopremone injection, triiodothyronine (T3) levels rose more and sooner than thyroxine (T4) levels.

Neither TSH elevation nor thyroid hormone elevation correlated with the euphoric response experienced by most subjects. This and other evidence suggests a central action of lopremone.

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